Product Description
In 1947, the mosquito-borne Zika virus (ZIKV) was first isolated from a rhesus monkey in the Zika forest of Uganda. In 1968, isolation from human hosts occurred in residents of Nigeria. Multiple studies have confirmed ZIKV antibody in humans from a multitude of countries in Africa and parts of Asia. In 2015, ZIKV first appeared outside of Africa and Asia when it was isolated in Brazil. ZIKV is closely related to other mosquito-borne flaviviruses such as the dengue, Japanese encephalitis, yellow fever, West Nile viruses. ZIKV causes a disease known as Zika fever, which is characterized by a macropapular rash covering the body, fever, joint pain, and malaise. ZIKV is an important emerging pathogen due to its appearance across the globe, mosquito-driven transmission cycle, and possible spread via sexual contact. Studies have shown that ZIKV can reside in blood transfusions and they can be a possible vector for human-to-human transmission. Diagnosis for ZIKV infection include PCR tests to detect viral DNA as well as additional tests to detect ZIKV antibody (IgM) in serum. IgM for ZIKV is typically detectable around 3-5 days after infection, but cross-reactivity with closely related dengue, yellow fever, Japanese encephalitis, and West Nile viruses are possible. There is no vaccine for ZIKV or treatment for Zika fever. Symptoms are relatively mild and only supportive therapy is employed. Zika Virus, Envelope, Recombinant, contains Histidine tag and reacts with both IgG and IgM. The E protein composes the majority of the virion surface and it is involved with replication, such as host cell binding and membrane fusion. Recombinant protein corresponding to Zika Virus Envelope, fused to His-tag, expressed in Sf-9 insect cells. Applications: Suitable for use in Lateral Flow. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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