Product Description
ANXA7, also known as annexin A7, is a member of the annexin family of calcium-dependent phospholipid binding proteins. The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. Structural analysis of the protein suggests that Annexin A7 is a membrane binding protein with diverse properties including voltage sensitive calcium channel activity, ion selectivity and membrane fusion. Recombinant protein corresponding to aa1-466 of human ANXA7, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~52.9kD Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMSYPGY PPTGYPPFPG PAPGGYPGAP QPGGAPSYPG VPPGQGFGVP PGGAGFSGYP IRPAANFDAI RDAEILRKAM KGFGTDEQAI VDVVANRSND AMQGAGTQER VLIEILCTRT NQEIREIVRC YQSEFGRDLE TDESCFNMIL ATRSFPQLRA TMEAYSRMAN RDLLSSVSRE IDLVQIKQMF AQMYQKTLGT MIAGDTSGDY RRLLLAIVGQ YPPAGQESSF PPSGQYPYPS GFPPMGGGAY PQVPSSGYPG AGGYPAPGGY QPPSQSYGGG PAQVPLPGGF PGGQMPSQYP GGQPTYPSQP ATVTQVTQGT QRQKIKAAFK TSYGKDLIKD LKSELSGNME ELILALFMPP TYYDAWSLRK KDIRSDTSGH FERLLVSMCQ GNRDENQSIN HQMAQEDAQR LYQAGEGRLG FSGYVESGLK TILQCALNRP AFFAERLYYA MKGAGTDDST LVRIVVTRSE Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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