BI-847325 is a novel ATP-competitive MEK and Aurora kinase inhibitor. It can inhibit the growth of BRAF resistant melanoma cells through suppression of Mcl-1 and MEK expression in human melanoma cell lines and mouse xenograft model. The efficacy of BI-847325 was studied in patients with refractory solid tumors. Synonyms: 3-[3-[[[4-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-2-propynamide, (Z)-3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide, BI 847325 CAS No: 1207293-36-4 Molecular Formula: C29H28N4O2 Molecular Weight: 464.56 Appearance: Crystalline solid Purity: 99% Solubility: DMF: 16mg/ml DMF:PBS(pH 7.2)(1:6): 0.14mg/ml DMSO: 5mg/ml Ethanol: 0.3mg/ml Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
464.56
Purity:
99%
Form:
Crystalline solid
CAS Number:
[1207293-36-4]
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