ICOS (CD278, Inducible T cell co stimulator, Activation inducible lymphocyte immunomediatory molecule, AILIM, MGC39850) (PE), IgG1, Clone: [7H152], Mouse, Monoclonal

Product Overview

• Article Name: ICOS (CD278, Inducible T cell co stimulator, Activation inducible lymphocyte immunomediatory molecule, AILIM, MGC39850) (PE), IgG1, Clone: [7H152], Mouse, Monoclonal
• Biozol Catalog Number: USB-I0650-01B
• Supplier Catalog Number: I0650-01B
• Alternative Catalog Number: USB-I0650-01B-120
• Manufacturer: US Biological
• Host: Mouse
• Category: Antikörper
• Application: FC, FLISA
• Immunogen: Human HPB-MLT cells, recombinant human ICOS-muIg

Product Description

The inducible costimulator (ICOS, T cell activation molecule H4) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Secondary signaling through CD28 or ICOS results in discrete cytokine secretion profiles by the activated T cells.1 Signaling by either molecule is effectively down regulated by CD152 (CTLA-4) engagement.2 Human GL50 is a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2), and has been shown to be the ligand for ICOS.3 Two RNA splice variants exist for this molecule, differing only in the cytoplasmic domain. 4 Functional Application: Antibody blocks binding of Recombinant GL50-muIg to ICOS Applications: Suitable for use in Flow Cytometry and FLISA. Other applications not tested. Recommended Dilution Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C before opening. DO NOT FREEZE! Stable at 4C as an undiluted liquid. Dilute only pror to immediate use. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [7H152]
• Isotype: IgG1
• Purity: Purified by Protein A affinity chromatography.
• Form: Supplied as a liquid in 50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% NaN3.