Human Transforming Growth Factor beta1 (TGF-beta1) is stimulatory for cells of mesenchymal origin and inhibitory for cells of epithelial or neuroectodermal origin. Mature TGF-beta1 is a disulfide-linked homodimer of two chains composed of 112aa residues each. There is a 70% homology between human TGF-beta1 and human TGF-beta2. Biological Activity: The biological activity of human TGF-beta1 is determined by measuring the acidification of the culture medium (Rat-1 cells) exposed to the growth factor. Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
25
Purity:
98% pure by non-reduced SDS gel electrophoresis. Purified by sequential chromatography.
Form:
Supplied as a liquid in 5mM HCl, pH 2.5.
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