Langerin / CD207 (Marker of Langerhans Cells)(LGRN/1821), CF568 conjugate, 0.1mg/mL

Produktübersicht

• Artikelname: Langerin / CD207 (Marker of Langerhans Cells)(LGRN/1821), CF568 conjugate, 0.1mg/mL
• Artikelnummer: BOT-BNC681821-100
• Hersteller Artikelnummer: BNC681821-100
• Alternativnummer: BOT-BNC681821-100-100UL
• Hersteller: Biotium
• Kategorie: Antikörper
• Spezies Reaktivität: Mouse
• Konjugation: CF568

Produktbeschreibung

Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2 -dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Produkteigenschaften

• Konzentration: 0.1 mg/mL
• Puffer: PBS, 0.1% BSA, 0.05% azide
• Quelle: Animal