DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1alpha stabilisation and accmulation in vitro and in vivo[1]. DMOG is an alpha-ketoglutarate analogue and inhibits alpha-KG-dependent hydroxylases. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal[2][4]. DMOG induces cell autophagy[5].
Molekulargewicht:
175.14
Reinheit:
99.77
CAS Nummer:
[89464-63-1]
Formel:
C6H9NO5
Target-Kategorie:
Autophagy,HIF/HIF Prolyl-Hydroxylase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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