Mcl 1 (Myeloid Cell Leukemia 1, MCL1, Mcl-1, Bcl 2 Related Protein EAT/Mcl1, Bcl-2-like Protein 3, BCL2L3, Bcl2-L-3, EAT, Induced Myeloid Leukemia Cell Differentiation Protein, Mcl1/EAT, MCL1L, MCL1S, MGC1839, MGC104264, Myeloid C

Produktübersicht

• Artikelname: Mcl 1 (Myeloid Cell Leukemia 1, MCL1, Mcl-1, Bcl 2 Related Protein EAT/Mcl1, Bcl-2-like Protein 3, BCL2L3, Bcl2-L-3, EAT, Induced Myeloid Leukemia Cell Differentiation Protein, Mcl1/EAT, MCL1L, MCL1S, MGC1839, MGC104264, Myeloid C
• Artikelnummer: USB-M2749-01C-BIOTIN
• Hersteller Artikelnummer: M2749-01C-Biotin
• Alternativnummer: USB-M2749-01C-BIOTIN-100
• Hersteller: US Biological
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Immunogen: Synthetic peptide corresponding to a 16 amino acid peptide located near the centre of human MCL-1.

Produktbeschreibung

Myeloid cell leukemia sequence 1 (MCL-1) is an anti-apoptotic member of the Bcl-2 family of proteins, first identified in differentiating ML-1 myeloid cells, and expressed in many different cell lines, tissues and a variety of tumors. The MCL-1 protein, localized to intracellular membranes and particularly mitochondrial membranes, has since been isolated in two distinct isoforms, known as MCL-1 long (MCL-1L) and MCL-1 short (MCL-1S). MCL-1S has been identified as a pro-apoptotic splice variant of MCL-1L, missing the transmembrane and BH1 and BH2 (Bcl-2 homology) domains. Interaction between these two antagonistic variants can act to regulate cell survival. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20C. Aliquots are stable at -20C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note: Applications are based on unconjugated antibody.

Produkteigenschaften

• Reinheit: Purified by Ion Exchange chromatography.
• Formulierung: Supplied as a liquid in PBS, pH 7.2. Labeled with Biotin.