Anti-integrin alpha5beta1 [7H5], Human IgG1, Fc Silent(TM), kappa, Monoclonal
Artikelnummer:
ABA-AB02665-10.3-BT
Hersteller Artikelnummer:
Ab02665-10.3-BT
Alternativnummer:
ABA-AB02665-10.3-BT
Hersteller:
Absolute Antibody
Wirt:
Human
Kategorie:
Antikörper
Applikation:
ELISA, FA, FC
Spezies Reaktivität:
Human
Alternative Synonym:
Integrin alpha-5, ITGA5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e
The original mouse version of this antibody was raised by immunizing mice with purified human alpha5beta1. Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
