PLC gamma 2 (PLCG2) Rabbit mAb, Unconjugated, Monoclonal

Produktübersicht

• Artikelname: PLC gamma 2 (PLCG2) Rabbit mAb, Unconjugated, Monoclonal
• Artikelnummer: ABB-A25017
• Hersteller Artikelnummer: A25017
• Alternativnummer: ABB-A25017-20UL,ABB-A25017-100UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, WB
• Spezies Reaktivität: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: FCAS3, APLAID, PLC-IV, PLC-gamma-2

Produktbeschreibung

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.

Produkteigenschaften

• Klonalität: Monoclonal
• Molekulargewicht: 148kDa
• NCBI: 5336
• UniProt: P16885
• Reinheit: Affinity purification
• Target-Kategorie: PLCG2

Anwendungsbeschreibung

• Application Verdünnung: WB,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Anwendungsbeschreibung: Cross-Reactivity: Human,Mouse. ResearchArea: Protein phosphorylation,Cancer,Signal Transduction,ErbB-HER Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology Developmental Biology,Cytoskeleton,Actins,Endocrine Metabolism,Lipid Metabolism,Immunology Inflammation,B Cell Receptor Signaling Pathway,Cardiovascular,Angiogenesis,Lipids. Shipping: Ice Bag

Bilder

Western blot analysis of lysates from RAW 264.7 cells using PLC gamma 2 (PLCG2) Rabbit mAb (A25017) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 90s.