The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Cross-Reactivity: Human. ResearchArea: Signal Transduction,Kinase,Tyrosine kinases,Cell Biology Developmental Biology,Apoptosis,Immunology Inflammation,CDs,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,Neuroscience, Cell Type Marker,Stem Cells,Hematopoietic Progenitors. Shipping: Ice Bag
Flow cytometry:1X10 6 Human PBMC were surface-stained with ABflo 450 Rabbit anti-Human CD45RA mAb (A27523,5 µl/Test) and APC Mouse IgG2a isotype control (A26377,5 µl/Test,left) or APC Mouse anti-Human CD45RO mAb (A27757,5 µl/Test,right). Cells in the lymphocytes gate were used for analysis.
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