This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene.
Cross-Reactivity: Human. ResearchArea: Immunology Inflammation,CDs,Stem Cells,Hematopoietic Progenitors,Cardiovascular,Blood. Shipping: Ice Bag
Flow cytometry:1X10 6 Human PBMC were surface-stained with ABflo 450 Rabbit anti-Human/Monkey CD3 mAb (A27177,5 µl/Test) and PerCP/Cyanine5.5 Rabbit IgG isotype control (A25620,5 µl/Test,left) or PerCP/Cyanine5.5 Rabbit anti-Human CD62L/L-Selectin mAb (A27922,5 µl/Test,right). Cells in the lymphocyte gate were used for analysis.
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