Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Konjugation:
ABflo 500
Alternative Synonym:
T14, S152, Tp55, TNFRSF7, S152. LPFS2
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Flow cytometry: 1X10 6 Human PBMC were surface-stained with PE Rabbit anti-Human/Monkey CD19 mAb (A26609,5 µl/Test) and ABflo500 Rabbit IgG isotype control (A25972,5 µl/Test,left) or ABflo 500 Rabbit anti-Human CD27 mAb (A28017,5 µl/Test,right). Cells in the lymphocyte gate were used for analysis.
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