Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Konjugation:
PE
Alternative Synonym:
IGFR, CD221, IGFIR, JTK13
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Cross-Reactivity: Human. ResearchArea: Protein phosphorylation,Cancer,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology Developmental Biology,Apoptosis,Growth factors,ESC Pluripotency and Differentiation,Immunology Inflammation,CDs,Cardiovascular,Angiogenesis. Shipping: Ice Bag
Flow cytometry: 1X10 6 C57BL/6 mouse splenocytes were surface-stained with ABflo 647 Rabbit anti-Human/Monkey CD3 mAb (A26284,5 µl/Test) and PE Rabbit IgG isotype control (A24172,5 µl/Test,left) or PE Rabbit anti-Human CD221alpha/IGF-1Ralpha mAb (A28122,5 µl/Test,right). Cells in the lymphocyte gate were used for analysis.
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