Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Konjugation:
ABflo 450
Alternative Synonym:
GP110, LAMP4, SCARD1
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
Cross-Reactivity: Human. ResearchArea: Immunology Inflammation,CDs. Shipping: Ice Bag
Flow cytometry:1X10 6 Human PBMC were surface-stained with PE Rabbit anti-Human/Monkey CD14 mAb (A25938,5 µl/Test) and then intracellularly-stained with ABflo 450 Rabbit IgG isotype control (A27451,5 µl/Test,left) or ABflo 450 Rabbit anti-Human CD68 mAb (A28159,5 µl/Test,right). Cells in the monocyte gate were used for analysis.
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