Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Konjugation:
ABflo 647
Alternative Synonym:
CD8, p32, Leu2, CD8alpha, CD8A
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein.
Cross-Reactivity: Dog. ResearchArea: Immunology Inflammation,CDs. Shipping: Ice Bag
Flow cytometry:1X10 6 Dog PBMC were surface-stained with ABflo 488 Rabbit anti-Dog CD4 mAb (A22687,5 µl/Test) and ABflo 647 Rabbit IgG isotype control (A22070,5 µl/Test,left) or ABflo 647 Rabbit anti-Dog CD8A mAb (A28328,0.5 µg,right). Cells in the lymphocyte gate were used for analysis.
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