Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Konjugation:
PE
Alternative Synonym:
Cd27l, CD27LG, Tnfsf7, Tnlg8a
CD70 is a type II transmembrane glycoprotein and a member of the tumor necrosis factor ligand superfamily (TNFSF), also known as CD27L and TNFSF7. It is constitutively expressed on medullary thymic epithelial cells. Its expression can be induced on activated lymphocytes (B cells, T cells, and NK cells) and dendritic cells. CD70 serves as the ligand for CD27, a co-stimulatory receptor that plays a critical role in T cell activation and proliferation. Overexpression of CD70 has been reported in various malignancies, such as renal cell carcinoma, glioblastoma, and non-small cell lung carcinoma, and it is being actively pursued as a therapeutic target.
Flow cytometry: 1X10 6 C57BL/6 mouse splenocytes (untreated,left) and C57BL/6 mouse splenocytes (treated with 1 µg/mL LPS and 2 µg/mL CD40 ligand for 4 days,right) were surface-stained with ABflo 488 Rabbit anti-Mouse CD19 mAb (A24100,5 µl/Test) and PE Rabbit anti-Mouse CD70 mAb (A28353,0.25 µg).
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