Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Konjugation:
ABflo 488
Alternative Synonym:
Il17, Ctla8, IL-17, Ctla-8, IL-17A
This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
FC (intra),0.25 µg per million cells in 100 µl volume
Anwendungsbeschreibung:
Cross-Reactivity: Mouse. ResearchArea: Immunology & Infectious Disease. Shipping: Ice Bag
Flow cytometry:1X10 6 C57BL/6 mouse splenocytes (untreated,left) and Th17-polarized C57BL/6 mouse splenocytes (treated with 50ng/ml PMA + 1ug/ml Ionomycin + 1ug/ml Brefeldin A for 6 hours,right) were surface-stained with ABflo 450 Rabbit anti-Mouse CD4 mAb (A25941,5 µl/Test) and then intracellularly-stained with ABflo 488 Rabbit anti-Mouse IL-17A mAb (A28399,0.25 µg).
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