Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Konjugation:
ABflo 488
Alternative Synonym:
R2, 4F9, C33, IA4, ST6, GR15, KAI1, SAR2, TSPAN27
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Flow cytometry: 1X10 6 Human PBMC were surface-stained with ABflo 450 Rabbit anti-Human/Monkey CD3 mAb (A27177,5 µl/Test) and ABflo488 Rabbit IgG isotype control (A22069,5 µl/Test,left) or ABflo 488 Rabbit anti-Human CD82 mAb (A28485,5 µl/Test,right). Cells in the lymphocyte gate were used for analysis.
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