CDKN1C/p57 Kip2 Rabbit mAb, Unconjugated, Monoclonal
Artikelnummer:
ABB-A6843
- Bilder (1)
| Artikelname: | CDKN1C/p57 Kip2 Rabbit mAb, Unconjugated, Monoclonal |
| Artikelnummer: | ABB-A6843 |
| Hersteller Artikelnummer: | A6843 |
| Alternativnummer: | ABB-A6843-20UL,ABB-A6843-100UL |
| Hersteller: | ABclonal |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. |
| Konjugation: | Unconjugated |
| Alternative Synonym: | BWS, WBS, p57, BWCR, KIP2, p57Kip2, CDKN1C/p57 Kip2 |
| This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. |
| Application Verdünnung: | WB,1:2000 - 1:8000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements. |
| Anwendungsbeschreibung: | Cross-Reactivity: Human. ResearchArea: Epigenetics Nuclear Signaling,Cancer,Signal Transduction,Kinase,Cell Biology Developmental Biology,Cell Cycle,Cell cycle inhibitors. Shipping: Ice Bag |
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Western blot analysis of lysates from HeLa cells using CDKN1C/p57 Kip2 Rabbit mAb (A6843) at 1:2000 dilutionincubated overnight at 4°C. HeLa cells were treated with Dexamethasone (500 nM) at 37°C for 16hrs . Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25 µg per lane. Blocking buffer: 3 % nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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