Lipin 1 Rabbit pAb, Unconjugated

Produktübersicht

• Artikelname: Lipin 1 Rabbit pAb, Unconjugated
• Artikelnummer: ABB-A8486
• Hersteller Artikelnummer: A8486
• Alternativnummer: ABB-A8486-20UL,ABB-A8486-100UL,ABB-A8486-1000UL,ABB-A8486-500UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, WB
• Spezies Reaktivität: Human
• Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: PAP1, Lipin 1

Produktbeschreibung

This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes.

Produkteigenschaften

• Klonalität: Polyclonal
• Molekulargewicht: 99kDa
• NCBI: 23175
• UniProt: Q14693
• Reinheit: Affinity purification
• Sequenz: TERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPMIEELKPPSASVVQTANKTDSPSRKRDKRSRHLGADGVYLDDLTDMDPEVAALYF
• Target-Kategorie: LPIN1
• Antibody Type: Primary Antibody

Anwendungsbeschreibung

• Application Verdünnung: WB,1:500 - 1:2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Anwendungsbeschreibung: Cross-Reactivity: Human,Mouse,Rat, ResearchArea: Signal Transduction,Cell Biology Developmental Biology,Cell Cycle,Cell differentiation,Endocrine Metabolism,Lipid Metabolism,Cholesterol Metabolism,Endocrine and metabolic diseases,Diabetes,Cardiovascular,Heart,Lipids,Cardiovascular diseases,Heart disease.

Bilder

Western blot analysis of lysates from rat skeletal muscle, using Lipin 1 Rabbit pAb (A8486) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 90s.