Phospho-STAT5A-S780 Rabbit pAb, Unconjugated

Produktübersicht

• Artikelname: Phospho-STAT5A-S780 Rabbit pAb, Unconjugated
• Artikelnummer: ABB-AP0139
• Hersteller Artikelnummer: AP0139
• Alternativnummer: ABB-AP0139-100UL, ABB-AP0139-20UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Spezies Reaktivität: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: MGF, STAT5, Phospho-STAT5A-S780

Produktbeschreibung

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

Produkteigenschaften

• Konzentration: WB
• Molekulargewicht: 91kDa
• NCBI: 6776
• UniProt: P42229
• Reinheit: Affinity purification
• Target-Kategorie: STAT5A

Anwendungsbeschreibung

• Application Verdünnung: WB,1:500 - 1:2000
• Anwendungsbeschreibung: Cross-Reactivity: Human, ResearchArea: Epigenetics Nuclear Signaling,Transcription Factors,Protein phosphorylation,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology Developmental Biology,Apoptosis,Immunology Inflammation,Jak-Stat-IL-6 Receptor Signaling Pathway,Stem Cells.

Bilder

Western blot analysis of lysates from K562 cells using Phospho-STAT5A-S780 Rabbit pAb (AP0139).
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% BSA.