Phospho-CD117/c-Kit-Y721 Rabbit pAb, Unconjugated

Produktübersicht

• Artikelname: Phospho-CD117/c-Kit-Y721 Rabbit pAb, Unconjugated
• Artikelnummer: ABB-AP0385
• Hersteller Artikelnummer: AP0385
• Alternativnummer: ABB-AP0385-100UL, ABB-AP0385-20UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Spezies Reaktivität: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: PBT, SCFR, C-Kit, CD117, MASTC, Phospho-CD117/c-Kit-Y721

Produktbeschreibung

This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

Produkteigenschaften

• Konzentration: WB
• Molekulargewicht: 110kDa
• NCBI: 3815
• UniProt: P10721
• Reinheit: Affinity purification
• Target-Kategorie: KIT

Anwendungsbeschreibung

• Application Verdünnung: WB,1:500 - 1:2000
• Anwendungsbeschreibung: Cross-Reactivity: Human, ResearchArea: Protein phosphorylation,Cancer,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology Developmental Biology,Growth factors,Immunology Inflammation,CDs,Cytokines,Neuroscience, Cell Type Marker,Stem Cells,Germline Stem Cells,Hematopoietic Progenitors.

Bilder

Western blot analysis of lysates from HeLa cells, using Phospho-CD117/c-Kit-Y721 Rabbit pAb (AP0385).
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% BSA.