Serum, plasma, cell culture supernatant, and other biological fluids.
Konjugation:
Biotin
Alternative Synonym:
ob, obese
Enables DNA binding activity and growth factor activity. Involved in several processes, including cell surface receptor signaling pathway, positive regulation of cytokine production, and positive regulation of signal transduction. Acts upstream of or within several processes, including insulin secretion, monocarboxylic acid metabolic process, and regulation of insulin secretion. Located in cytoplasm and extracellular space. Is expressed in several structures, including adipose tissue, alimentary system, central nervous system, early conceptus, and genitourinary system. Used to study abdominal obesity-metabolic syndrome (multiple), fatty liver disease (multiple), obesity, and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence, congenital leptin deficiency, liver disease (multiple), lung disease (multiple), and type 2 diabetes mellitus. Orthologous to human LEP (leptin).
