Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.
Lyophilized from a 0.22 µm filtered solution of PBS, pH 7.4 with 50 µg BSA per 1 µg as a carrier protein.
Target-Kategorie:
Csf1, Csfm
Application Verdünnung:
Lyophilized from a 0.22 µm filtered solution of PBS, pH 7.4 with 50 µg BSA per 1 µg as a carrier protein.
Anwendungsbeschreibung:
Cross-Reactivity: Reconstitute to a concentration of 100 µg/mL in sterile PBS. Avoid vortex or vigorously pipetting the protein. Aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Cytokines & Cytokine receptors,Cell Culture related
Recombinant Mouse CSF-1/M-CSF Protein was determined by SDS-PAGE under reducing (R) and non-reducing (NR) conditions.
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