Biotinylated Recombinant Human LMP2 (HLA-A*02:01) Complex Protein

Produktübersicht

• Artikelname: Biotinylated Recombinant Human LMP2 (HLA-A*02:01) Complex Protein
• Artikelnummer: ABB-RP02755
• Hersteller Artikelnummer: RP02755
• Alternativnummer: ABB-RP02755-100UG
• Hersteller: ABclonal
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Immunogen: Gly25-Thr305(HLA-A*02:01),Ile21-Met119(B2M) and CLGGLLTMV peptide
• Alternative Synonym: MHC, RMF, LMP2, LMP-2, Macropain chain 7, Proteasome chain 7, PSMB9, RING12

Produktbeschreibung

The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of malignant tumors that highly express LMP2.

Produkteigenschaften

• Konzentration: < 1 EU/µg of the protein by LAL method.
• Molekulargewicht: 50.3 kDa
• UniProt: A0A140T913
• Reinheit: 95 % as determined by Tris-Bis PAGE, 95 % as determined by HPLC.
• Target-Kategorie: LMP2 (HLA-A*02:01) Complex

Anwendungsbeschreibung

• Anwendungsbeschreibung: Cross-Reactivity: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles. ResearchArea: Other Recombinant Protein