IL24, MDA7, ST16, Interleukin-24, IL-24, Melanoma differentiation-associated gene 7 protein, MDA-7, Suppression of tumorigenicity 16 protein
Interleukin-24 (IL-24) also known as Melanoma differentiation-associatedgene 7 protein (MDA-7) is a member of the IL10 family of cytokines. IL24/MDA-7/IL24 can induce apoptosis selectively in various cancer cells.Overexpression of IL-24 leads to elevated expression of several GADDfamily genes, which correlates with the induction of apoptosis. Thephosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), andheat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced bythis gene in melanoma cells, but not in normal immortal melanocytes.Human IL-24/MDA-7/IL24 is secreted by activated peripheral bloodmononuclear cells and is the ligand for two heterodimeric receptors, IL22R1/IL-20R2 and IL-20R1/IL-20R2. Northern blot analysis revealed IL24/MDA-7/IL24 expression in human tissues associated with the immunesystem such as spleen, thymus, peripheral blood leukocytes and normalmelanocytes. IL-24/MDA-7/IL24 binding to either its endogenous receptorson human keratinocytes or to ectopically expressed receptors on babyhamster kidney cells leads to activation of the signal transducers andactivators of transcription.
Lyophilized from a 0.22 µm filtered solution of PBS, pH 7.4.Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Target-Kategorie:
IL24, MDA7, ST16
Application Verdünnung:
Lyophilized from a 0.22 µm filtered solution of PBS, pH 7.4.Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Anwendungsbeschreibung:
Cross-Reactivity: Centrifµge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Cytokines & Cytokine receptors
Recombinant Human IL-24 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
