Infliximab, a chimeric anti-TNF-alpha monoclonal antibody, is used to treat psoriasis, Crohns disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis. Infliximab interferes TNF-alpha from binding to its receptor in the cell.Mainly produced by activated macrophages (M1), Tumor necrosis factor (TNF, cachexin, cachectin, tumor necrosis factor alpha, TNFalpha) plays important roles in the regulation of autoimmune reaction.
