Human CD20 Monoclonal Antibody, Endotoxin 0.05 EU/mg
Artikelnummer:
ABB-YR0054
Hersteller Artikelnummer:
YR0054
Alternativnummer:
ABB-YR0054-5MG,ABB-YR0054-20MG
Hersteller:
ABclonal
Kategorie:
Antikörper
Applikation:
ELISA, NeA
Immunogen:
Human CD20
Alternative Synonym:
B1, S7, Bp35, MS4A1, FMC7, CVID5, LEU-16
B-lymphocyte antigen CD20 encoded by the MS4A1 gene is an activated-glycosylated phosphoprotein on the surface of all B-cells. The function of the membrane protein is to stimulate B-cell immune response, specifically against T-independent antigens though its natural ligand remains unknown. CD20 is important for the development and differentiation of B-cells into plasma cells. CD20 belongs to the membrane-spanning 4A family with common structural features, similar intron/exon splice boundaries, and unique expression patterns among hematopoietic cells and nonlymphoid tissues.Rituximab, a chimeric anti-CD20 monoclonal antibody, destroys B cells and is used to treat diseases with excessive numbers of B cells, overactive B cells, or dysfunctional B cells, such as many lymphomas, leukemias, transplant rejection, and autoimmune disorders.
