Human EGFR Monoclonal Antibody, Endotoxin 0.05 EU/mg
Artikelnummer:
ABB-YR0098
Hersteller Artikelnummer:
YR0098
Alternativnummer:
ABB-YR0098-5MG,ABB-YR0098-20MG
Hersteller:
ABclonal
Kategorie:
Antikörper
Applikation:
ELISA, NeA
Immunogen:
Human EGFR
Alternative Synonym:
ERBB, ERRP, HER1, mENA, ERBB1, PIG61, NISBD2
Nimotuzumab Biosimilar uses the same protein sequences as the therapeutic antibody nimotuzumab.Like cetuximab, nimotuzumab is a humanized monoclonal antibody that binds to the epidermal growth factor receptor (EGFR), a signalling protein that normally controls cell division. In some cancers, this receptor is altered to cause uncontrolled cell division, a hallmark of cancer. These monoclonal antibodies block EGFR and stop the uncontrolled cell division.It has a humanized human-mouse h-R3 heavy chain and a humanized human-mouse h-R3 kappa-chain.Nimotuzumab binds with optimal affinity and high specificity to the extracellular region of EGFR (epidermal growth factor receptor). This results in a blockade of ligand binding and receptor activation. Epidermal growth factor receptor (EGFR) is a key target in the development of cancer therapeutics. EGFR-targeting drugs have been shown to improve response when used with conventional treatments such as radiation therapy and chemotherapy.
