Monoclonal Antibody to ATF6 (Clone: ABM1A40), Clone: [ABM1A40], Mouse

Artikelnummer: ABI-10-1018
Artikelname: Monoclonal Antibody to ATF6 (Clone: ABM1A40), Clone: [ABM1A40], Mouse
Artikelnummer: ABI-10-1018
Hersteller Artikelnummer: 10-1018
Alternativnummer: ABI-10-1018-100UG
Hersteller: Abeomics
Wirt: Mouse
Kategorie: Antikörper
Applikation: FACS, WB
Spezies Reaktivität: Human
Immunogen: A partial length recombinant ATF6 protein (amino acids 1-400) was used as the immunogen for this antibody.
Alternative Synonym: ATF6
ATF6, also named as Cyclic AMP-dependent transcription factor ATF-6 alpha is a member of bZIP family, ATF subfamily. ATF6 forms homodimer and heterodimer with ATF6-beta. ATF6 acts by activating specific unfolded protein response target genes during endoplasmic reticulum stress. ATF6 is a ubiquitously expressed transcription factor located at endoplasmic reticulum (ER) membrane. During ER stress an approximately 50 kDa fragment containing the N-terminal cytoplasmic domain is cleaved by proteolysis and is translocated into the nucleus. N-glycosylation may serve as a sensor for ER homeostasis. For the binding of ATF6 to ERSE, ESRE should first bind to another transcription factor called Nuclear Transcription Factor Y (NF-Y). ATF6 could also be involved in activation of transcription by interacting with serum response factor. ATF6 is a 74 kDa protein and is highly expressed in kidney, liver, colon and mammary gland.
Klonalität: Monoclonal
Klon-Bezeichnung: [ABM1A40]
NCBI: 22926
UniProt: P18850
Reinheit: Protein G Chromatography
Formulierung: Purified
Target-Kategorie: ATF6
Application Verdünnung: Western blot analysis: 2-4 µg/ml, FACS: 0.5-1 µg/10 6 cells