Monoclonal Antibody to Bcl-2 (Clone: BC1), Clone: [BC1], Mouse
Artikelnummer:
ABI-10-1052-25
Hersteller Artikelnummer:
10-1052-25
Alternativnummer:
ABI-10-1052-25-25UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FACS, IHC, WB
Spezies Reaktivität:
Human
Immunogen:
A synthetic peptide corresponding to amino acids 41-54 (GAAPAPGIFSSQPG-Cys), of human Bcl-2 was used as immunogen.
Alternative Synonym:
BCL2
Bcl-2 (B-cell lymphoma 2), is a member of Bcl-2 family of regulator proteins. These proteins contain a hydrophobic cleft that binds to BH3-only proteins and to the pro-apoptotic Bcl-2 family members Bad, Bak, and Bax to inhibit apoptosis. In the absence of this binding, the proapoptotic Bcl-2 members are recruited to the OMM (Outer Mitochondrial Membrane) at which they oligomerize and cause OMM permeabilization, releasing proapoptotic effectors such as SMAC or cytochrome-c. Bcl-2 also neutralize a group of sensor proteins (such as BIM), which are triggered by cytotoxic stimuli such as chemotherapy. BCL-2 proteins therefore have a central role as guardians against apoptosis, helping cancer cells to evade cell death.
