Recombinant anti-human-IL-1 beta Antibody (Canakinumab), Other, Monoclonal

Produktübersicht

• Artikelname: Recombinant anti-human-IL-1 beta Antibody (Canakinumab), Other, Monoclonal
• Artikelnummer: ABI-10-2003
• Hersteller Artikelnummer: 10-2003
• Alternativnummer: ABI-10-2003-50UG
• Hersteller: Abeomics
• Wirt: Other
• Kategorie: Antikörper
• Applikation: ELISA, FA, FACS, ICC, IHC, IP
• Spezies Reaktivität: Human
• Alternative Synonym: Interleukin-1 beta, Catabolin

Produktbeschreibung

Target: IL-1 Beta Generic name: Canakinumab Product Origin: Recombinant in CHO cells Canakinumab is a recombinant, human anti-human-IL-1betamonoclonal antibody that belongs to the IgG1/kappa isotype subclass with a molecular mass of 145157 Daltons when deglycosylated. Canakinumab binds to human IL-1betaand neutralizes its inflammatory activity by blocking its interaction with IL-1 receptors, but it does not bind IL-1alpha or IL-1 receptor antagonist (IL-1ra). References: 1. Church LD, McDermott MF: Canakinumab, a fully-human mAb against IL-1beta for the potential treatment of inflammatory disorders. Curr Opin Mol Ther. 2009 Feb,11(1):81-89. 2. Lachmann HJ, et al.: Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med. 2009 Jun 4,360(23):2416-25. doi:10.1056/NEJMoa0810787

Produkteigenschaften

• Klonalität: Monoclonal
• NCBI: 3553
• UniProt: P01584
• Reinheit: Purity: >98.0% as determined by SEC-HPLC & SDS-PAGE.
• Formulierung: Purified

Anwendungsbeschreibung

• Application Verdünnung: Specificity: Human IL1 beta. Does not cross react with other members of the interleukin-1 family. Inquire for more than 1 mg quantities. Availability 5-7 weeks.