Monoclonal antibody to MyD88 (Clone: ABM2H20), Clone: [ABM2H20], Mouse
Artikelnummer:
ABI-10-3012-25
Hersteller Artikelnummer:
10-3012-25
Alternativnummer:
ABI-10-3012-25-25UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FACS, WB
Spezies Reaktivität:
Human, Mouse
Immunogen:
A partial length recombinant protein of human MyD88 (amino acids 13-221) was used as an immunogen for this antibody.
Alternative Synonym:
Myeloid differentiation primary response protein MyD88
MyD88 (Myeloid differentiation factor) is an essential adaptor molecule in all TLR (Toll-like receptor) signaling pathways except TLR3. MyD88 is composed of an N-terminal (Death Domain) and a highly conserved C-terminal TIR (Toll/interleukin-1 Receptor) domain. It is found to stimulate IL-1R/IL18R-mediated signaling. MyD88-dependent signaling is also important in the regulation of innate as well as acquired immunity, in particular, T-cell responses, to various microbial pathogens. After activation of TLRs, MyD88 is phosphorylated and subsequently recruits IRAKs (IL-1R Associated Kinases) and other downstream proteins such as TRAF6, finally resulting in activation of the NF-kappaB (nuclear factor kappa B) pathway.
