Monoclonal Antibody to Dectin-2 (Clone: ABM2H28), Clone: [ABM2H28], Mouse
Artikelnummer:
ABI-10-4013-25
Hersteller Artikelnummer:
10-4013-25
Alternativnummer:
ABI-10-4013-25-25UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FACS, IHC, WB
Spezies Reaktivität:
Human, Mouse
Immunogen:
A partial length recombinant Dectin-2 protein (amino acids 70-230) was used as the immunogen for this antibody.
Alternative Synonym:
CLEC6A||CLECSF10||DECTIN2
Dectin-2 (C-type lectin domain family 6 member A) is a type II membrane receptor with an extracellular C-type lectin-like domain fold. Dectin-2 plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. It binds high-mannose carbohydrates in a Ca(2+)-dependent manner. In Dectin-2 glycosylation occurs at Asn131, Asn170. Dectin-2 has 2 isoforms produced by alternative splicing. Dectin-2 is strongly expressed in monocytes and weakly in B-cells and also expressed in spleen, tonsils, lymph node, lungs, leukocytes, dendritic cells and bone marrow.
