Monoclonal Antibody to CLEC9A (Clone: ABM23H8), Clone: [ABM23H8], Mouse
Artikelnummer:
ABI-10-4020
Hersteller Artikelnummer:
10-4020
Alternativnummer:
ABI-10-4020-100UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human
Immunogen:
A partial length recombinant protein ( a.a 15-218) of CLEC9A was used as the immunogen for this antibody.
Alternative Synonym:
C-type lectin domain family 9 member A, CLEC9A
CLEC9A is a C-type lectin receptor involved in the sensing and presentation of antigens derived from necrotic cells. It is expressed on the surface of the mouse and human dendritic cell subsets specialized for the uptake and processing of material from dead cells. CLEC9A is expressed at the cell surface as a glycosylated dimer and can mediate endocytosis, but not phagocytosis. It possesses a cytoplasmic immunoreceptor tyrosine-based activation-like motif that can recruit Syk kinase and can induce proinflammatory cytokine production. CLEC9A provides targeted recruitment of the adaptive immune system during infection and can also be utilized to enhance immune responses generated by vaccines.
