Monoclonal Antibody to IL-23R (Clone: ABM25G4), Clone: [ABM25G4], Mouse
Artikelnummer:
ABI-10-4030-25
Hersteller Artikelnummer:
10-4030-25
Alternativnummer:
ABI-10-4030-25-25UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FACS, WB
Spezies Reaktivität:
Human
Immunogen:
A partial length recombinant protein (a.a 250-450) of IL-23R was used as the immunogen for this antibody.
Alternative Synonym:
Interleukin-23 receptor, IL-23 receptor, IL-23R
IL-23, a member of the IL-12 cytokine family, is composed of a p40 subunit, which is shared with IL-12, and a p19 subunit, with an approximate molecular weight of 60 kDa. IL-23 is produced by activated dendritic cells and macrophages in response to microorganisms. IL-23 promotes Th17 cells producing TNF-a, IL-17, IL-6, IL-22, GM-CSF, and other novel factors, which are associated with the induction of autoimmune inflammation. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.
