Monoclonal Antibody to CD73 (Clone: ABM4F11), Clone: [ABM4F11], Mouse
Artikelnummer:
ABI-10-4107-25
Hersteller Artikelnummer:
10-4107-25
Alternativnummer:
ABI-10-4107-25-25UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FACS, WB
Spezies Reaktivität:
Human
Immunogen:
A partial length recombinant CD73 protein (amino acids 145-346) was used as the immunogen for this antibody.
Alternative Synonym:
NT5E||NT5||NTE
CD73, also known as ecto-5-nucleotidase, is a glycosyl-phosphatidylinositol linked plasma membrane glycoprotein that is expressed on multiple cell types and in different tissues. It is a key enzyme in the regulation of purinergic signaling and inflammatory reactions. It hydrolyzes extracellular AMP into adenosine, which dampens immune cell activation, and reduces leukocyte trafficking CD73 potently suppresses antitumor T cell responses through its ability to generate adenosine. It has also emerged as an important regulator of tissue homeostasis and pathophysiologic responses related to immunity, inflammation, pain, ischemia, tissue fibrosis and cancer.
Western blot analysis: 2-4 µg/ml, FACS analysis: 0.5-1 µg/10 6 cells
Fig-1: Cell Surface flow analysis of hCD73 in PBMC (Lymphocytes) using 0.2µg/10 6 cells of CD73 clone ( ABM4F11). Green represents isotype control, red represents anti-hCD73 antibody. Goat anti-mouse PE conjugated secondary antibody (ABEOMICS) was used.
Fig-2: Western blot analysis of CD73. Anti- CD73 antibody (Clone: ABM4F11) was tested at 2 µg/ml on human liver lysate.
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