Monoclonal Antibody to TRF2 (Clone: ABM10H3), Clone: [ABM10H3], Mouse
Artikelnummer:
ABI-10-6002-25
Hersteller Artikelnummer:
10-6002-25
Alternativnummer:
ABI-10-6002-25-25UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC, WB
Spezies Reaktivität:
Human
Immunogen:
Full length recombinant TRF2 protein was used as the immunogen for this antibody.
Alternative Synonym:
TERF2||TRBF2||TRF2
TRF2 (Telomere Repeat Binding Factor 2), a subunit of the shelterin complex, binds to duplex telomeric DNA and plays a crucial role in telomere protection. TRF2 contains an N-terminal basic domain rich in glycines and arginines (the GAR domain), a central TRFH dimerization domain, a flexible linker region and a C-terminal Myb-like DNA binding domain. TRF2 undergoes extensive post-translational modification, which in turn regulates its stability, DNA binding and cellular localization. Ubiquitylation of TRF2 by Siah1, an E3 ligase, promotes TRF2 degradation and replicative senescence of human primary fibroblasts. TRF2 is phosphorylated in response to DNA damage and this phosphorylation has been implicated in DNA double strand break repair.
