Monoclonal Antibody to ALK-1 (Clone: ABM43C4), Clone: [ABM43C4], Mouse
Artikelnummer:
ABI-10-7542
Hersteller Artikelnummer:
10-7542
Alternativnummer:
ABI-10-7542-100UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC, WB
Spezies Reaktivität:
Human
Immunogen:
A partial length recombinant ALK-1 protein (amino acids 310-503) was used as the immunogen for this antibody
Alternative Synonym:
ACVRL1||ACVRLK1||ALK1
ALK-1 or Activin receptor-like kinase-1 is a type I cell surface receptor for the TGF-beta (transforming growth factor-beta) super family of proteins. It is expressed predominantly in endothelial cells with moderate expression in smooth muscle cells, myofibroblast, hepatic stellate cells, chondrocytes, monocytes, myoblasts, macrophages and fibroblasts. ALK-1 plays a pivotal role in vascular remodelling and angiogenesis. More specifically its key function is in arterial/venous differentiation during embryonic vascular development. Mutations in ALK-1 gene (12q11-14) causes HHT2 (Hereditary Haemorrhagic Telangiectasia type 2), an autosomal dominant multisystem vascular dysplasia caused by a haploinsufficiency mechanism.
