Monoclonal Antibody to E-cadherin (Clone: ABM43F8), Clone: [ABM43F8], Mouse
Artikelnummer:
ABI-10-7546
Hersteller Artikelnummer:
10-7546
Alternativnummer:
ABI-10-7546-100UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC, WB
Spezies Reaktivität:
Human
Immunogen:
A partial length recombinant E-cadherin protein (amino acids 438-556) was used as the immunogen for this antibody .
Alternative Synonym:
CDH1||CDHE||UVO
Epithelial cadherin (E-cadherin) is a calcium dependent cell-cell adhesion glycoprotein. It is associated with gland formation, stratification, and epithelial polarization. Its deregulation affects cell-cell adhesion and results in increased invasiveness of distinct human carcinomas like gastric cancer, malignancy, oral squamous cell carcinoma, Atypical parathyroid adenoma (APA). Loss of function of E-cadherin leads to the disappearance of epithelial characteristics of the cells and generates higher invasiveness for extracellular matrices. E-cadherin expression is considered to be a decisive indicator for differentiation, aggressive behaviour, high proliferation, metastasis, poor prognosis and invasiveness of human carcinoma cells.
