A partial length recombinant Dach1 protein (amino acids 300-550) was used as the immunogen for this antibody.
Alternative Synonym:
DACH1||DACH
DACH1, originally discovered in drosophila eye development, is an essential member of RDGN (Retinal Determination Gene Network). This protein behaves as a tumor suppressor, and its expression is reduced in several cancers. The ectopic expression of DACH1 inhibits cellular proliferation in vitro and tumor growth in vivo. DACH1 is richly expressed in embryonal kidney cells and adult kidney tissues, but dramatically decreases in renal cancer cells.
