Recombinant Mouse Monoclonal Antibody to NKX2.2 (Neuroendocrine & Ewings Sarcoma Marker)(Clone : rNX2/294), Clone: [rNX2/294]

Produktübersicht

• Artikelname: Recombinant Mouse Monoclonal Antibody to NKX2.2 (Neuroendocrine & Ewings Sarcoma Marker)(Clone : rNX2/294), Clone: [rNX2/294]
• Artikelnummer: ABI-12-1009-20
• Hersteller Artikelnummer: 12-1009-20
• Alternativnummer: ABI-12-1009-20-20UG
• Hersteller: Abeomics
• Kategorie: Sonstiges
• Applikation: IHC
• Spezies Reaktivität: Human
• Immunogen: Human full-length recombinant NKX2.2 protein
• Alternative Synonym: Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman

Produktbeschreibung

Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [rNX2/294]
• NCBI: 4821
• UniProt: O95096
• Reinheit: Purified Ab with BSA and Azide at 200ug/ml
• Formulierung: Purified
• Target-Kategorie: NKX2.2 (Neuroendocrine & Ewing s Sarcoma Marker)
• Antibody Type: Recombinant Antibody

Anwendungsbeschreibung

• Application Verdünnung: Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes),