Recombinant Rabbit Monoclonal Antibody to CD99 / MIC2 (Ewing s Sarcoma Marker)(Clone : MIC2/1495R), Clone: [MIC2/1495R]
Artikelnummer:
ABI-12-1031
Hersteller Artikelnummer:
12-1031
Alternativnummer:
ABI-12-1031-100UG
Hersteller:
Abeomics
Kategorie:
Sonstiges
Applikation:
IHC
Spezies Reaktivität:
Human
Immunogen:
Recombinant human full-length MIC2 protein
Alternative Synonym:
12E7, E2 antigen, MIC 2X, MIC 2Y, MIC2, Protein MIC2, Surface antigen MIC2, T-cell surface glycoprotein E2
Recognizes a sialoglycoprotein of 27-32kDa, identified as CD99, or MIC2 gene product, or E2 antigen. MIC2 gene is located in the pseudo-autosomal region of the human X and Y chromosome. MIC2 gene encodes two distinct proteins, which are produced by alternative splicing of the CD99 gene transcript and are identified as bands of 30 and 32kDa (p30/32). Although its function is not fully understood, CD99 is implicated in various cellular processes including homotypic aggregation of T cells, upregulation of T cell receptor and MHS molecules, apoptosis of immature thymocytes and leukocyte diapedesis. CD99 is expressed on the cell membrane of some lymphocytes, cortical thymocytes, and granulosa cells of the ovary. Most pancreatic islet cells, Sertoli cells of the testis, and some endothelial cells express this antigen. Mature granulocytes express very little or no CD99. MIC2 is strongly expressed on Ewing s sarcoma cells and primitive peripheral neuroectodermal tumors.
Immunohistochemistry (Formalin-fixed) (5-10µg/ml for 30 min at Room Temp)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes),
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