Recombinant Rabbit Monoclonal Antibody to PDCD1 / PD1 / CD279 (Programmed Cell Death 1)(Clone : PDCD1/1410R), Clone: [PDCD1/1410R]

Produktübersicht

• Artikelname: Recombinant Rabbit Monoclonal Antibody to PDCD1 / PD1 / CD279 (Programmed Cell Death 1)(Clone : PDCD1/1410R), Clone: [PDCD1/1410R]
• Artikelnummer: ABI-12-1033-20
• Hersteller Artikelnummer: 12-1033-20
• Alternativnummer: ABI-12-1033-20-20UG
• Hersteller: Abeomics
• Kategorie: Sonstiges
• Applikation: IHC
• Spezies Reaktivität: Human
• Immunogen: Human recombinant PDCD1 protein fragment (exact sequence is proprietary)
• Alternative Synonym: CD279, hPD-1, hSLE1, PD1, PDCD1, Programmed Cell Death Protein 1, Protein PD-1, SLEB2, Systemic lupus erythematosus susceptibility 2

Produktbeschreibung

PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [PDCD1/1410R]
• NCBI: 5133
• UniProt: Q15116
• Reinheit: Purified Ab with BSA and Azide at 200ug/ml
• Formulierung: Purified
• Target-Kategorie: PDCD1 / PD1 / CD279 (Programmed Cell Death 1)
• Antibody Type: Recombinant Antibody

Anwendungsbeschreibung

• Application Verdünnung: Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes)