B cell lineage specific activator, BSAP, EBB-1, KLP, Paired box 5
The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. The PAX5 gene is a member of theipaired box (PAX)ifamily of transcription factors. The central feature of this gene family is a novel, highly conservediDNA-binding domain, known as theipaired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thoµght to contribute toineoplastic transformation. The PAX5 gene encodes theiB-cellilineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development andispermatogenesis.
