Myosin regulatory light chain (Myl) 9 is a regulatory subunit of the ATPase myosin protein. Myl9 regulates actin rearrangement to direct cellular migration, shape, and adhesion. Myl9 itself is regulated by post-translational modifications, including phosphorylation, acetylation and methylation. Phosphorylation of Myl9 at Thr18 and Ser19 promotes myosin ATPase activity and interaction with actin. N alpha-acetylation of Myl9 has been shown to increase Ser19 phosphorylation and cytoplasmic activity, while N alpha-methylation promotes DNA binding in the nucleus. Myl9, Myl12a, and Myl12b (Myl9/12) have been identified as functional ligands for CD69 in inflamed lungs, playing a major role in chronic inflammatory disorders such as chronic rhinosinusitis. Homozygous deletion in the MYL9 gene in humans has been identified as a putative molecular basis of the disease megacystis-microcolon-intestinal hypoperistalsis (MMIHS) syndrome, especially considering Myl9s role in contracting smooth muscle cell.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[AWBMyl9F6 F-6]
Formulierung:
Purified
Application Verdünnung:
1µg/mL - 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.
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