Anti-SARS-CoV-2 RBD antibody(DM55), Rabbit mAb, Clone: [DM55], Monoclonal

Produktübersicht

• Artikelname: Anti-SARS-CoV-2 RBD antibody(DM55), Rabbit mAb, Clone: [DM55], Monoclonal
• Artikelnummer: ABI-12-9409
• Hersteller Artikelnummer: 12-9409
• Alternativnummer: ABI-12-9409-100UG
• Hersteller: Abeomics
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, FACS
• Immunogen: Recombinant SARS-CoV-2 (2019-nCoV) S protein RBD (Arg 319-Phe541) produced by using human HEK293 cells
• Alternative Synonym: SARS-CoV-2 RBD

Produktbeschreibung

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as Covid19 (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. The spike protein is a type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which accounts for recognizing the cell surface receptor, ACE2. S2 contains basic elements needed for the membrane fusion. Recent publications indicate that S1-RBD domain can induce virus neutralizing-antibody and T cell response.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [DM55]
• Reinheit: Purified from cell culture supernatant by affinity chromatography
• Antibody Type: Monoclonal Antibody

Anwendungsbeschreibung

• Application Verdünnung: Recommended Dilutions ELISA 1/5000-10000,FACS 1/100

Bilder

Figure 1. Elisa plate pre-coated by 2 µg/ml (100µl/well) SARS-CoV-2 RBD protein can bind Rabbit Anti-SARS-CoV-2 RBD monoclonal antibody (clone:DM55) in a linear range of 0.1-100 ng/ml.

Figure 2. Competition FACS assay demonstrating Rabbit anti-RBD monoclonal antibody (clone: DM55) blockade of SARS-CoV-2 (COVID-19) S protein RBD (1µg/ml, ) binding to Expi 293 cell line transfected with human ACE2. IC50=816.4ng/ml. The Y-axis represents the geometric mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.