GATA3 Leeporter(TM) Luciferase Reporter-HEK293 Cell Line Preis auf Anfrage

Produktübersicht

• Artikelname: GATA3 Leeporter(TM) Luciferase Reporter-HEK293 Cell Line Preis auf Anfrage
• Artikelnummer: ABI-14-109ACL
• Hersteller Artikelnummer: 14-109ACL
• Alternativnummer: ABI-14-109ACL-1VIAL
• Hersteller: Abeomics
• Kategorie: Zellen/Zellkultur
• Applikation: FA

Produktbeschreibung

The GATA3 Leeporter(TM) Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the GATA3 response element, so that the cell line is designed to measure the transcriptional activity of GATA3. As a zinc-finger transcription factor, GATA3 (GATA-binding protein 3) plays a critical role in early and late T cell differentiation, which regulates Th1/Th2 differentiation. GATA3 has been shown to induce Th2 differentiation and repress Th1 differentiation. GATA3 is also known to promote the secretion of IL-4, IL-5 and IL-13 from Th2 cells. The GATA3 induction by phorbol 12-myristate 13-acetate (PMA) is shown in Figure 1.

Anwendungsbeschreibung

• Application Verdünnung: Application: Monitor the GATA3 signaling pathway activity. Screen for activators or inhibitors of the GATA3 signaling pathway. Culture conditions: Cells should be grown at 37C with 5% CO2 using DMEM medium (w/ L-Glutamine, 4.5g/L Glucose and Sodium Pyruva