Nrf2 Leeporter(TM) Luciferase Reporter-MCF7 Cell Line Preis auf Anfrage

Produktübersicht

• Artikelname: Nrf2 Leeporter(TM) Luciferase Reporter-MCF7 Cell Line Preis auf Anfrage
• Artikelnummer: ABI-14-117ACL
• Hersteller Artikelnummer: 14-117ACL
• Alternativnummer: ABI-14-117ACL-1VIAL
• Hersteller: Abeomics
• Kategorie: Zellen/Zellkultur
• Applikation: FA

Produktbeschreibung

The Nrf2 Leeporter(TM) Luciferase Reporter cell line is a stably transfected MCF7 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the antioxidant response element (ARE). ARE is known to regulate expression and induction of various detoxifying enzyme genes in response to antioxidants and xenobiotics, and is primarily regulated by the Keap1-Nrf2 pathway in which induction and nuclear translocation of Nrf2 mediated by antioxidants and xenobiotics results in the binding of Nrf2 to ARE leading to the expression of defensive genes. The Nrf2 induction by dimethyl fumarate (DMF) is shown in Figure 1.

Anwendungsbeschreibung

• Application Verdünnung: Application: Monitor the Nrf2 induction activity. Screen for activators or inhibitors of the Nrf2 signaling pathway. Culture conditions: Cells should be grown at 37C with 5% CO2 using Advanced Minimum Essential Medium (Advanced MEM, e.g. Gibco 12491) supp